Detroit went through a street renumbering in 1921. The address 250 25th Street became about 1101 25th Street. Without spending too many hours looking up the existence of this place, I can say that it was definitely there in aerial photographs on 4/13/56. And it was gone by 5/30/61. By the looks of the ground and the lack of vegetation in the 1961 photo, I'd guess that the demolition happened in 1960 or 61. In the 1956 image, you can barely see that curved front walkway.

The interstate wiped out this neighborhood.

The large upstairs porches were often used as sleeping quarters for people with tuberculosis. It was thought that exposure to fresh air helped cure the patients, even in a Michigan winter.

Because I was not sure of the difference between a sanitarium and a sanitorium. A brief search later, I had this explanation:

The definition of the words is often not clear; however, with a few exceptions, sanatoriums (with an 'or') served people with tuberculosis and sanitariums (with an 'ar') were for people with a variety of illnesses who needed to convalesce.

That being the case, my late maternal grandmother (1918-1981) was once consigned to a sanitorium for a short while, in Louisiana where she lived. My mother was old enough at the time to remember it. Only, Elizabeth, or Mamaw as I would later call her, did not have tuberculosis. She had been misdiagnosed. When the doctors discovered their mistake, they sent her home to resume her domestic duties and live out her life, which was eventually cut off by pancreatic cancer.

[Sanatorium, or sanitorium? - Dave]

Like the lovely Queen Anne style design. Wonder who built this as the original mansion. The interior alterations from home to hospital must have been interesting, along with the background of the staff.

Trying to identify the car. Maybe a 1908 Maxwell Runabout. Looks like it has a mother-in-law seat in the rear -- away from the driver and passenger. No covered top and out in the wind.

... at 829 West Grand Boulevard in Detroit, a former mansion turned into a private hospital. It began in 1903 not far away at 251 West 25th Street and seems to have lasted until 1925 or so.

[Thank you for the brilliant detective work! Although I think this is at the 25th Street address. - Dave]